Mycoplasma: The Simplest Prokaryotic Cell

Mycoplasma, also known as PPLO- are the simplest prokaryotic cell. 


Mycoplasma is a group of small parasitic bacteria that lacks cell walls and can survive without oxygen and generally resistant to antibiotics and can cause pneumonia and urinary tract infections in animals and humans. 

Few common species of mycoplasma are:

Mycoplasma gallisepticum 

Mycoplasma pneumoniae 

Mycoplasma hominis 

Mycoplasma geniculatum 

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Good to know:

  1. PPLO stands for Pleuro pneumonia like organism.
  2. Parasite: those organisms lives on a biotic host (anothar organism) and derived nutrients from it are called parasite.


Mycoplasmas are first discovered by Louis Pasteur in 1843 while he was studying the cusative agent pleuro-pneumonia in cattle. He designated this agent as PPLO. 

But Pasteur could not isolate it in its culture or see under a microscope as it was too small. Later, Nocard and Roux in 1898 were successful in obtaining pure culture of this microorganism in media obtaining serum. 



Mycoplasmas are frequent contaminants in tissue culture rich in organic matter. They have also been found in hot water springs. They occur in soil, sewage water and they also occur in humans, animals and plant body. 

Morphology or Structure of a Mycoplasma Cell


Characteristics of Mycoplasma

  • Unicellular prokaryotic living organism.
  • Cell wall absent. Plasmamembrane forms the outer boundary of the cells.
  • Size: Very minute; .1 – .3 micro meter in diameter. In rare cases, it can reach about .9 micrometer. 
  • It is a bit larger than the biggest virus Vaccinea, but smaller than the smallest bacteria.
  • Smallest mycoplasma: Mycoplasma laidlawii.
  • Shape: Generally round. However, sometimes it may be pear-shaped, filamentous or branched.
  • Nature: Heterotrophic, saprophytic, parasitic and sometimes free-living.

Internal structures

  • 40 kinds of different enzymes are present in soluble protein particle.
  • Single DNA duplex in cell. Lack histones.


  1. Binary fission: Figure
  2. Spore formation: Figure


  1. Pneumonia in human and cattle.
  2. Urinary tract infection in human and cattle.


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Shariful Islam
Shariful Islam
2 years ago

Good article.
Life cycle of Mycoplasma is necessary for this article.

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1 month ago

Your point of view caught my eye and was very interesting. Thanks. I have a question for you.

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